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Program

 

Workshop for Early Career Investigators and Students on “Translational Research”

Saturday Dec 12th 2015

13:00 Registration

13:20 - 13:35 Welcome and Introductory remarks (Chairs: Maria Contel and Angela Casini)

13:35 - 14:35 Training Session I - “Techniques in translational research to assess anticancer drug activity in vitro and in vivo” - Speaker: Christian Gaiddon (Directeur de Recherche CNRS, Head Team INSERM "Molecular mechanisms of the stress response and pathologies", FR)

14:35 - 15:35 Training Session II – “Ex vivo methods to assess drug toxicity, metabolism and cellular accumulation”- Speaker: Geny Groothuis (Head of Department of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute of Pharmacy, University of Groningen, NL)

Coffee break 25 min

16:00 - 17:00 Training Session III- “Running Clinical Trials for Cancer Chemotherapy. A Clinicians Approach” Speaker: Prof. Aminah Jatoi (Mayo Clinic, US)

17:00 - 18:00 Round Table - Chair: Rudolf K. Allemann - “Career Advice in the Drug Discovery Field. Opportunities in Companies, Academia and Federal Agencies. Opportunities for Individuals from Underrepresented Groups”.
Speakers: Dr. Jacek Capala (NCI, Program Director, Clinical Radiation Oncology Branch, US), Dr. Reinhold Penner (Director of Research, Center for Biomedical Research, The Queen's Medical Center UHCC Cancer Biology Program, CyThera Pharmaceuticals, US) 

 

CEMM symposium

Sunday Dec 13th 2015

9:00 Registration

9:30 - 9:45 Welcome and Introductory remarks

Session I - “Unconventional anticancer metallodrugs – part A”
Chairs: Kim Dunbar & Christian Hartinger

9:45 - 10:20 - Keynote 1 - Peter Sadler (University of Warwick, UK) – “Precious metal anticancer complexes with new mechanisms of action”

10:20 - 10:40 - Seiji Komeda (Suzuka University of Medical Science, JP) – “In vivo highly antitumor-active dinuclear platinum(II) complexes  with multimodal DNA bindings”

10:40 - 11:00 Christian Gaiddon (CNRS Strasbourg, FR) - “Targeting redox enzymes of the endoplasmic reticulum with organometallic compounds: treats and tricks leading to cancer cell death”

Coffee break – 25 min

Chairs: Claudia Turro & Ana Costa Ferreira

11:25 - 11:55 - Invited Lecture – Lena Ruiz Azuara (UNAM, MX) – “Study of the mechanism of action of the mixed chelates compounds register as Casiopeinas and the bridge to Clinic Phase I”

11:55 - 12:15 - Timo Völker (Philipps-Universität Marburg, DE) – "Transition-Metal-Mediated Uncaging in Living Human Cells – An Emerging Alternative to Photolabile Protecting Groups"

2 flash oral presentations
Networking lunch and Poster session – 1 h 30 min

Chairs: Anne Vessieres& Curt Davey

13:55 - 14:15 - Ulrich Bierbach (Wake Forest University, US) - “Challenges in the preclinical development of highly cytotoxic platinum-acridine anticancer agents"

14:15 - 14:35 - Valentina Gandin (University of Padova, IT) – “Phosphino copper(I) complexes as antitumor agents”

14:35 - 14:45 - Highlights - Janice Aldrich-Wright (University of Western Sydney, AU) – “Unconventional platinum complexes”

14:45 - 14:55 - Highlights - Ana Maria da Costa Ferreira (University of São Paulo, BR) – “Cytotoxicity of Multifunctional Heterodinuclear Oxindolimine Complexes containing Copper and Platinum”


Session II – “New targets for anticancer metallodrugs” 

Chairs: Gilles Gasser & Lena Ruiz Azuara

14:55 - 15:30 - Keynote 3 - Walter Berger (Medical University of Vienna, AT) – “Novel targets and targeting approaches for anticancer metal drugs”

15:30 - 16:00 - Invited Lecture - Sue Berners Price (Griffith University, AU) – “Metalloglycomics - new approaches and new targets in the design of metal-based anticancer drugs”

16:00 - 16:20 - Curt A. Davey (Nanyang Technological University, SG) – “Could the Histone Proteins that Package DNA into Chromatin be Neglected Therapeutic Targets?”

Coffee break – 25 min

Chairs: Christian Gaiddon & Raymond Wai-Yin Sun

16:45 - 17:05 – Christian Hartinger (University of Auckland, NZ) – “Metallodrugs: from potential targets to target identification”

17:05 - 17:25 - Rudolf K. Allemann (Cardiff University, UK) – “Conformationally Restricted Calpain Inhibitors”

17:25 - 17:45 - Zong-Wan Mao (Sun Yat-Sen University, CN) – “The molecular or subcellular organelle-targeted metal-based anticancer theranostic agents”

17:45 - 18:05 - Maria Pia Rigobello (University of Padova, IT) – “Inhibition of thioredoxin reductase: Consequences in mitochondrial pathophysiology”

18:05 - 18:15 - Highlights – Andreia de Almeida (University of Groningen, NL) – “Targeting Aquaglyceroporin function with gold(III)-based compounds: new opportunities for therapeutic applications”

18:15 - 18:25 - Highlights – Isolda Romero Canelon (University of Warwick, UK) - “Cellular Redox Balance and the Mechanism of Action of Osmium-organometallic Anticancer Drugs”

Networking Reception


Monday 14th Dec 2015

Session III - “Unconventional anticancer metallodrugs – part B”
Chairs: Trevor Hambley & Ulrich Bierbach

8:00 - 8:35 Keynote 4 - Kim Dunbar (Texas A&M University, US) – “Dirhodium(II,II) Complexes for Photoactivated Chemotherapy”

8:35 - 8:55 - Ingo Ott (Technische Universität Braunschweig, DE) – “Gold Organometallics in Medicinal Chemistry and Drug Design"

8:55 - 9:15 - Zijian Guo (Nanjing University, CN) – “Functionalization of Platinum(II) Anticancer Complexes”

9:15 - 9:35 - Benelita T. Elie (Brooklyn College, City University of New York, US) – “Preclinical Studies of Two Unconventional Anticancer Agents as Promising Candidates for Breast and Renal cancers”

9:35 - 9:55 – Chiara Nardon (University of Padova, IT) – “Leading-edge gold(III) targeted chemotherapeutics in translational oncology”

9:55 - 10:05 - Highlights – Dinorah Gambino (Universidad de la República, UY) – “Heteroleptic oxidovanadium(IV) complexes of salicylaldimines and polypyridyl ligands: cytotoxicity and mechanism of action”

10:05 - 10:15 - Highlights - Alexey Nazarov (Moscow State University, RU) - “Ru(II)arene-Fe and Ru(III)-Fe compounds: synthesis and antiproliferative activity”

Coffee break – 25 min

Session IV - “Mechanisms of resistance and toxicity”
Chairs: Sue Berners-Price & Valentina Gandin

10:40 - 11:15 - Keynote 5 - Stephen B. Howell (UC San Diego Moores Cancer Center, US) – “Control of resistance to the platinum drugs”

11:15 - 11:45 - Invited Lecture - Geny Groothuis (University of Groningen, NL) – “Application of human and animal precision-cut tissue slices for toxicity testing of metallodrugs”

11:45 - 11:55 - Highlights - Denise de Oliveira Silva (Universidade de São Paulo, BR) – “Effect of axial ligands in the Ru2(II,III)-Ibuprofen paddlewheel structured metallodrug on the response of human glioblastoma cells to proliferation, apoptosis, mitosis and cell migration”

2 flash oral presentations

Networking lunch and Poster session - 1 h 30 min

13:30 - 14:30 - Plenary lecture - Stephen J. Lippard (MIT, US) - "Third Row Transition Metal Complexes for Treating Cancer"

Coffee break 20 min

14:50 - 16:10 - Round Table – Chair: Gianni Sava - “Update on new clinical trials of metallodrugs”  
Speaker: Aminah Jatoi (Mayo Clinic, US) – “Testing Auranofin – a Gold Compound – as an Antineoplastic Agent in Ovarian Cancer Patients”

Chairs: Angela Casini & Walter Berger
16:10 - 16:45 - Keynote 6 - Hilary A. Calvert (University College London Hospitals, UK) – “The interactions of platinum drugs with DNA repair systems”

16:45 - 17:05 - James Turkson (University of Hawaii Cancer Center, US) –“Therapeutic modulators of Jak/Stat signaling for human diseases”

 

Social Dinner
(Willows Restaurant, Buses will leave from UHCC at 17:30, for registered participants in this event only)

 

Tuesday 15th 2015

Session V- “Activation and drug delivery strategies”
Chairs: Maria Contel & Ingo Ott

8:00 - 8:35 - Keynote 7 - Claudia Turro (Ohio State University, US) - "Ru(II) Complexes for Dual Photoinduced Reactivity as Potential Therapeutics"

8:35 - 9:05 - Invited Lecture - Trevor Hambley (University of Sydney, AU) - “Coordination Chemistry in the Targeted Delivery of Anticancer Agents”

9:05 - 9:25 - Gilles Gasser (University of Zurich, CH) – “Towards the use of Ru(II) Polypyridyl Complexes as Photosensitizers in Photodynamic Therapy”

9:25 - 9:45 - Raymond Wai-Yin Sun (Shantou University, CN) - “Gold(I) Complexes: Fluorescent Probes of Cysteine, Anti-Migratory Agents of Cisplatin-Resistant Cancer Cells and the Synergism with Metal-Organic Frameworks”
9:45 - 10:05 - Jin-Gang Liu (East China University of Science and Technology, CN) – “Nitric oxide mediated targeted photodynamic therapy under NIR light by a multifunctional NO-delivery nanoplatform”

Coffee break 25 min

Chairs: Peter Sadler & Dinorah Gambino

10:30 - 11:05 Keynote 8 - Anne Vessieres (CNRS Paris, FR) – “Ferrocifen Constructs Against Cancer Resistant to Apoptosis”

11:00 - 11:20 - Guangyu Zhu (City University of Honk Kong, HK) – “Dual-targeting non-traditional platinum compounds and Pt-loaded inorganic nanoparticles to improve cisplatin’s anticancer activity”

11:20 - 11:50 - Invited Lecture - Debbie Crans (Colorado State University, US) – “Speciation and its importance in drug administration and mode of action of metal based drugs"

11:50 - 12:00 - Highlights – Roberto S. da Silva (Universidade de São Paulo, BR) – “Photobiological studies of ruthenium complex as potentiation for photodynamic therapy. Kinetic, photobiological and cytotoxicity studies”

Networking Lunch - 1 h

Chair: Gianni Sava and Debbie Crans

13:00 - 13:35 - Keynote 9 – Nick Farrell (Virginia Commonwealth University, US) – “Polynuclear Platinums: lessons learned and future directions”

13:35 - 13:55 - James D. Hoeschele (Eastern Michigan University, US) – “Kiteplatin – a Potential Clinical Candidate Showing Significant Activity vs. Oxaliplatin-Resistant Colorectal Cancer”

13:55 - 15:15 - Roundtable – Chair: Walter Berger “Translational Research in Drug Discovery”.
Speakers: Chris Orvig (University of British Columbia, CA) – “Insulin-Enhancing Vanadium Compounds: Chemistry, Conundrum and Commercialization”, Reinhold Penner (Center for Biomedical Research, The Queen's Medical Center UHCC Cancer Biology Program & CyThera Pharmaceuticals), James Turkson (University of Hawaii Cancer Center, US)

Coffee break 20 min

15:35 - 16:05 - Invited Lecture – Dr. Jacek Capala (NCI, Program Director, Clinical Radiation Oncology Branch) - “SBIR NIH/NCI 346: Molecularly Targeted Radiation Therapy For Cancer Treatment Program”

16:05 - 16:15 - Angela Casini and Joe W. Ramos – “An overview of International Networks activities: lessons learned on metallodrugs development and perspectives”

16:15 - 16:40 - Poster Prizes and Closing Remarks